The Supreme Court issued a ruling on March 9,

1841, freeing the remaining 35 survivors of the Amistad mutiny. Although seven of the nine justices on the court hailed from Southern states, only one dissented from Justice Joseph Story's majority opinion. Private donations ensured the Africans' safe return to Sierra Leone in January 1842. The events leading up to the decision began on July 2, 1839, when Joseph Cinqué led fifty-two fellow captive Africans, recently abducted from the British protectorate of Sierra Leone by Portuguese slave traders, in a revolt aboard the Spanish schooner Amistad. The ship's navigator, who was spared in order to direct the ship back to western Africa, managed, instead, to steer it northward. When the Amistad was discovered off the coast of Long Island, New York, it was hauled into New London, Connecticut by the U.S. Navy. President Martin Van Buren, guided in part by his desire to woo pro-slavery votes in his upcoming bid for reelection, wanted the prisoners returned to Spanish authorities in Cuba to stand trial for mutiny. A Connecticut judge, however, issued a ruling recognizing the defendants' rights as free citizens and ordering the U.S. government to escort them back to Africa.

The U.S. government eventually appealed the case to the Supreme Court. Former president John Quincy Adams, who represented the Amistad Africans in the Supreme Court case, argued in his defense that it was the illegally enslaved Africans, rather than the Cubans, who "were entitled to all the kindness and good offices due from a humane and Christian nation." Adams's victory in the Amistad case was a significant success for the abolition movement.